Medicinal Natural Products

Автор(ы):Dewick Paul M.
06.10.2007
Год изд.:2002
Описание: "Не читал. По названию можно сказать, что книга про "медицинские натуральные продукты", что уже противоречит само себе. Значит, вам нужно прочитать эту книгу и прислать хоть какую-нибудь рецензию, а то по оглавлению я тоже ни черта не понял. Может продукты какие действительно классные."
Оглавление:
Medicinal Natural Products — обложка книги.
1 ABOUT THIS BOOK, AND HOW TO USE IT [1]
  The Subject [1]
  The Aim [1]
  The Approach [2]
  The Topics [2]
  Be Selective [2]
  To Learn, or to Understand? [3]
  Conventions Regarding Acids, Bases, and Ions [3]
  Nomenclature [3]
  Some Common Abbreviations [4]
  Further Reading [4]
2 SECONDARY METABOLISM: THE BUILDING BLOCKS AND CONSTRUCTION ECHANISMS [7]
  Primary and Secondary Metabolism [7]
  The Building Blocks [8]
  The Construction Mechanisms [12]
  Alkylation Reactions: Nucleophilic Substitution [12]
  Alkylation Reactions: Electrophilic Addition [13]
  Wagner-Meerwein Rearrangements [15]
  Aldol and Claisen Reactions [15]
  Schiff Base Formation and the Mannich Reaction [18]
  Transamination [20]
  Decarboxylation Reactions [20]
  Oxidation and Reduction Reactions [24]
    Dehydrogenases [24]
    Oxidases [25]
    Mono-oxygenases [25]
    Dioxygenases [27]
    Amine Oxidases [28]
    Baeyer-Villiger Oxidations [28]
  Phenolic Oxidative Coupling [28]
  Glycosylation Reactions [29]
  Some Vitamins Associated with the Construction Mechanisms [30]
    Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6, Vitamin B12, Vitamin H
  Further Reading [33]
3 THE ACETATE PATHWAY: FATTY ACIDS AND POLYKETIDES [35]
  Saturated Fatty Acids [36]
  Unsaturated Fatty Acids [40]
    Fixed Oils and Fats, Evening Primrose Oil Acetylenic Fatty Acids [47]
  Branched-Chain Fatty Acids [48]
  Prostaglandins [51]
    Prostaglandins Isoprostanes
  Thromboxanes [58]
    Thromboxanes
  Leukotrienes [58]
    Leukotrienes
  Aromatic Polyketides [60]
  Cyclization: Simple Phenols [61]
  Structural Modifications: Anthraquinones [63]
    Senna, Cascara, Frangula, Allied Drugs, Hypericum/St John's Wort
  C-Alkylation Reactions [72]
    Mycophenolic Acid, Khellin and Cromoglicate
  Phenolic Oxidative Coupling [76]
    Griseofulvin
  Oxidative Cleavage of Aromatic Rings [78]
  Starter Groups Other Than Acetate [79]
    Poison Ivy and Poison Oak, Aflatoxins, Cannabis, Tetracyclines, Anthracycline Antibiotics
  Macrolides and Polyethers [92]
  Extender Groups other than Malonate [92]
    Macrolide Antibiotics, Avermectins, Polyene Antifungals, Tacrolimus and Sirolimus, Ansa Macrolides
  Cyclization Through Diels-Alder Reactions [111]
    Mevastatin and other Statins
  Genetic Manipulation of the Acetate Pathway [114]
  Further Reading [117]
4 THE SHIKIMATE PATHWAY: AROMATIC AMINO ACIDS AND PHENYLPROPANOIDS [121]
  Aromatic Amino Acids and Simple Benzoic Acids [121]
    Folic Acid (Vitamin B9), Chloramphenicol
  Cinnamic Acids [130]
  Lignans and Lignin [132]
  Podophyllum Phenylpropenes [135]
    Volatile Oils Containing Principally Aromatic Compounds
  Benzoic Acids from CeC3 Compounds [141]
  Coumarins [142]
  Dicoumarol and Warfarin, Psoralens Styrylpyrones [147]
    Kava
  Flavonoids and Stilbenes [149]
  Flavonolignans [151]
  Silybum marianum Isoflavonoids [154]
  Phyto-oestrogens, Derris and Lonchocarpus Terpenoid Quinones [158]
  Vitamin E, Vitamin К Further Reading [164]
5 THE MEVALONATE AND DEOXYXYLULOSE PHOSPHATE PATHWAYS: TERPENOIDS AND STEROIDS [167]
  Hemiterpenes (C(?)) [172]
  Monoterpenes (С(?)) [172]
    Volatile Oils Containing Principally Terpenoid Compounds
  Irregular Monoterpenes [186]
    Pyrethrins
  Iridoids (С(?)) [187]
    Valerian
  Sesquiterpenes (Cis) [191]
    Feverfew, Chamomile and Matricaria, Artemisia annua and Artemisinin, Gossypol, Trichothecenes
  Diterpenes (C2(?)) [203]
    Taxus brevifolia and Taxol (Paclitaxel), Ginkgo biloba, Forskolin
  Sesterterpenes (C(?)) [212]
  Triterpenes (C3(?)) [212]
  Triterpenoid Saponins [219]
    Liquorice, Quillaia, Ginseng
  Modified Triterpenoids [225]
  Tetraterpenes (C(?)) [226]
    Vitamin A
  Higher Terpenoids [231]
  Steroids [232]
  Stereochemistry [232]
  Cholesterol [233]
    Cholesterol
  Steroidal Saponins [237]
    Dioscorea, Fenugreek, Sisal, Sarsaparilla, Yucca
  Cardioactive Glycosides [241]
    Digitalis purpurea, Digitalis lanata, Strophanthus, Convallaria, Squill, Toxic Plants
  Phytosterols [252]
    Soya Bean Sterols, Fusidic Acid
  Vitamin D [257]
    Vitamin D
  Bile Acids [260]
    Bile Acids
  Adrenocortical Hormones/Corticosteroids [262]
  Semi-Synthesis of Corticosteroids [264]
    Corticosteroid Drugs
  Progestogens [267]
    Progestogen Drugs
  Oestrogens [272]
    Oestrogen Drugs, Aromatase Inhibitors, Oestrogen Receptor Antagonists
  Androgens [282]
  Androgen Drugs Further Reading [285]
6 ALKALOIDS [291]
  Alkaloids Derived from Ornithine [292]
  Pyrrolidine and Tropane Alkaloids [292]
    Belladonna, Stramonium, Hyosycamus, Duboisia, Allied Drugs, Hyoscyamine,
    Hyoscine and Atropine, Coca
  Pyrrolizidine Alkaloids [305]
  Alkaloids Derived from Lysine [307]
  Piperidine Alkaloids [307]
  Lobelia [308]
  Quinolizidine Alkaloids [309]
  Indolizidine Alkaloids [310]
  Alkaloids Derived from Nicotinic Acid [311]
  Pyridine Alkaloids [311]
    Vitamin B3, Tobacco, Areca
  Alkaloids Derived from Tyrosine [315]
  Phenylethylamines and Simple Tetrahydroisoquinoline Alkaloids [315]
    Catecholamines, Areca, Lophophora, Curare
  Modified Benzyltetrahydroisoquinoline Alkaloids [327]
  Opium [329]
  Phenethylisoquinoline Alkaloids [341]
    Colchicum
  Terpenoid Tetrahydroisoquinoline Alkaloids [343]
    Ipecacuanha
  Amaryllidaceae Alkaloids [345]
    Galanthamine
  Alkaloids Derived from Tryptophan [346]
  Simple Indole Alkaloids [347]
    5-Hydroxytryptamine (Serotonin), Psilocybe
  Simple p-Carboline Alkaloids [349]
  Terpenoid Indole Alkaloids [350]
    Rauwolfia, Catharanthus, Iboga, Nux-vomica, Ellipticine
  Quinoline Alkaloids [359]
    Cinchona, Camptothecin
  Pyrroloindole Alkaloids [365]
    Physostigma
  Ergot Alkaloids [368]
    Ergot, Morning Glories
  Alkaloids Derived from Anthranilic Acid [376]
  Quinazoline Alkaloids [377]
  Quinoline and Acridine Alkaloids [377]
  Alkaloids Derived from Histidine [379]
  Imidazole Alkaloids [379]
    Pilocarpus
  Alkaloids Derived by Animation Reactions [381]
  Acetate-derived Alkaloids [381]
    Conium maculatum
  Phenylalanine-derived Alkaloids [382]
    Ephedra, Khat
  Terpenoid Alkaloids [385]
  Steroidal Alkaloids [388]
    Solarium Alkaloids
  Purine Alkaloids [394]
    Caffeine, Theobromine, and Theophylline, Coffee, Tea, Cola, Cocoa, Mate Tea, Guarana
  Saxitoxin and Tetrodotoxin [396]
  Saxitoxin, Tetrodotoxin Further Reading [398]
7 PEPTIDES, PROTEINS, AND OTHER AMINO ACID DERIVATIVES [405]
  Peptides and Proteins [405]
  Ribosomal Peptide Biosynthesis [407]
  Peptide Hormones [410]
  Thyroid Hormones [410]
    Thyroxine, Calcitonin
  Hypothalamic Hormones [411]
    Thyrotrophin-Releasing Hormone, Luteinizing Hormone-Releasing Hormone, Growth Hormone-Releasing Hormone/Factor, Somatostatin
  Anterior Pituitary Hormones [413]
    Corticotropin, Growth Hormone, Prolactin, Gonadotrophins
  Posterior Pituitary Hormones [413]
    Oxytocin, Vasopressin
  Pancreatic Hormones [416]
    Insulin, Glucagon
  Interferons [417]
    Interferons
  Opioid Peptides [417]
  Enzymes [419]
  Nonribosomal Peptide Biosynthesis [421]
  Peptide Antibiotics [423]
    Cycloserine, Polymyxins, Bacitracins, Tyrothricin and Gramicidins, Capreomycin, Vancomycin and Teicoplanin, Bleomycin, Cyclosporins, Streptogramins, Dactinomycin
  Peptide Toxins [433]
    Death Cap (Amanita phalloides), Ricin, Botulinum Toxin, Microcystins, Snake Venoms
  Modified Peptides: Penicillins, Cephalosporins, and Other p-Lactams [422]
  Penicillins [422]
    Penicillins
  Cephalosporins [444]
    Cephalosporins, Cephamycins, Carbacephems
  Other P-Lactams [450]
    Clavulanic Acid, Carbapenems, Monobactams
  Cyanogenic Glycosides [455]
  Glucosinolates [457]
  Cysteine Sulphoxides [460]
  Garlic Further Reading [461]
8 CARBOHYDRATES [465]
  Monosaccharides [465]
  Oligosaccharides [469]
    Monosaccharides and Disaccharides, Vitamin С
  Polysaccharides [473]
    Polysaccharides
  Aminosugars [477]
  Aminoglycosides [478]
    Aminoglycoside Antibiotics, Streptamine-containing Antibiotics,
    2-Deoxystreptamine-containing Antibiotics, Acarbose, Lincomycin and Clindamycin
  Further Reading [486]
Index [487]
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Размер:9029044 байт
Язык:ENG
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